ABSTRACT
Objects: To compare the medical records of inpatients with acute angle-closure glaucoma(AACG) in the period of pandemic 2022(2022.12.9-2023.1.19) , and the same time period of last three years.To analyses covid-19 infection-related conditions in patients with AACG of the pandemic 2022. Methods: Patients with AACG who first hospitalized for surgical treatment in the ophthalmology department of the First Affiliated Hospital of Nanjing Medical University from 2022.12.9 to 2023.1.19(after the adjustment of China's pandemic prevention policies) were included, and the patients of same time of last three years,(2019group:2019.12.9-2020.1.19, pandemic 2020:2020.12.9-2021.1.19 and pandemic 2021:2021.12.9-2022.1.19).These inpatients’ medical records were compared.During the period from 2022.12.9 to 2023.1.19,patients with acute ACG who were first diagnosed or first hospitalized for surgical treatment, an online questionnaire was administered, and whether they had glaucoma attacks during COVID-19 infection was used as a subgroup question to compare the two groups of people with AACG in general differences in conditions. Results: A total of 114 patients (135 operated eyes) with medical records were included：24 (28 eyes) of 2019 group，27 (27 eyes) of pandemic 2020,29(37eyes)of pandemic 2021 and 34 (43 eyes) of pandemic 2022 respectively. 72 patients participated in the questionnaire. The number of patients hospitalized for surgery for AACG in the period following the COVID-19 pandemic was significantly higher by approximately 41.6% compared to the 2019 group, accounting for a significantly higher percentage (p=0.004),a significant difference in the status of comorbid systemic disease and comorbid hypertension among surgically treated patients (p=0.042, p=0.010) Significant difference in the rate of trabeculectomy(Trab) for glaucoma decreasing from year to year (p=0.019) and a significant increasing trend in the rate of goniosynechialysis(GSL) (p=0.007) Whether the pandemic environment or viral infection precipitates glaucoma attacks may be related to whether patients drink alcohol (p=0.028) and whether they have combined hypertension (p=0.014). Conclusion: The COVID-19 pandemic may promote an increase in the number of patients with AACG, and COVID-19 infection has the potential to contribute to the attack of primary angle-closure glaucoma.